The minimum and recommended PC system specifications for Rainbow Six: Siege have been confirmed by Ubisoft, and they should be very achievable for the majority of PC gamers.
MINIMUM
Supported OS
Windows 7, Windows 8.1, Windows 10 (64bit versions required)
Processor
Intel Core i3 560 @ 3.3 GHz or AMD Phenom II X4 945 @ 3.0 GHz
RAM
6GB
Video Card
NVIDIA GeForce GTX 460 or AMD Radeon HD 5870 (DirectX-11 compliant with 1GB of VRAM) [See list of supported video cards down below]
DVD ROM Drive
DVD-ROM Dual Layer
Sound
DirectX 9.0c compatible sound card with latest drivers
Hard Drive
30GB
Multiplayer
Broadband connection with 256kbps upstream or faster
RECOMMENDED
Windows 7 SP1, Windows 8.1, Windows 10 (64bit versions required)
Intel Core i5-2500K @ 3.3 GHz or better or AMD FX-8120 @ 3.1 Ghz or better
8GB
NVIDIA GeForce GTX 670 (or GTX 760 / GTX 960) or AMD Radeon HD 7970 (or R9 280x [2GB VRAM] / R9 380 / Fury X) [See list of supported video cards down below]
DirectX 9.0c compatible sound card 5.1 with latest drivers
47GB
Broadband connection with 512kbps upstream or faster
At launch the game will support the following graphics cards:
NVIDIA
GeForce GTX 460 or better, GTX 560 or better, GTX 650 or better, GTX 750 or better, or any card from the GT900 and Titan Series
AMD
Radeon HD5870 or better, HD6870 or better, HD7770 or better, R7 260X or better, or any card from the R-300 series and Fury X
Rainbow Six: Siege launches December 1 for PC, Xbox One and PS4.
Source: Ubi Blog